منابع مشابه
Spitz tumors in children: a grading system for risk stratification.
OBJECTIVE To describe a grading system for risk stratification of atypical Spitz tumors in children and adolescents. In some circumstances, unequivocal distinction between Spitz nevus and melanoma is practically impossible. It is likely that these lesions for which we lack specific diagnostic criteria represent a broad histological continuum extending from benign to malignant tumors. Therefore,...
متن کاملHypopigmented atypical Spitzoid neoplasms (atypical Spitz nevi, atypical Spitz tumors, Spitzoid melanoma): a clinicopathological update
The clinicopathologic classification, diagnosis, and management of Spitzoid melanocytic lesions is one of the most problematic topics in dermato-oncology and dermatopathology. After earlier anecdotal reports [1,2], the controversial history of these controversial lesions began in 1948 when Sophie Spitz described 13 cases of what she called “juvenile melanoma,” underlining its presumably good pr...
متن کاملActivating MET Kinase Rearrangements in Melanoma and Spitz Tumors
Oncogenic gene fusions have been identified in many cancers and many serve as biomarkers or targets for therapy. Here we identify six different melanocytic tumours with genomic rearrangements of MET fusing the kinase domain of MET in-frame to six different N-terminal partners. These tumours lack activating mutations in other established melanoma oncogenes. We functionally characterize two of th...
متن کاملLong-term outcome of Spitz-type melanocytic tumors.
OBJECTIVE Despite recent advances in our molecular understanding of Spitz-type tumors, the clinical behavior of these lesions remains unclear. We thus set out to define the clinical outcome of classic Spitz nevi, atypical Spitz tumors (ASTs), and spitzoid melanomas. DESIGN From 1987 through 2002, data on all lesions containing the term "Spitz" or "Spitz" [AND] "melanoma" were retrieved from t...
متن کاملSerological investigations in children with colonized Spitz-Holter valves.
It has been found that children with hydrocephalus, whose Spitz-Holter valves are colonized with Staph. albus, have an antibody to this organism in their serum. Children without colonized shunts have little or no such antibody. A test for this antibody is described, and its use in such cases is discussed.
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ژورنال
عنوان ژورنال: Archives of Dermatology
سال: 1999
ISSN: 0003-987X
DOI: 10.1001/archderm.135.3.282